Leo Tyrell is the name of several members of House Tyrell.
- Lord Leo Tyrell, also known as Leo Longthorn, the Lord of Highgarden during the reign of King Daeron II Targaryen
- Ser Leo Tyrell, the son of Ser Victor Tyrell. Husband to Lady Alys Beesbury
- Leo Tyrell, also known as Lazy Leo, the son of Ser Moryn Tyrell. A novice the Citadel