A regent is in charge of ruling the realm when the current king is underage or incapable of ruling due to injury or illness. The regent's rule ends on the the king's sixteenth name day or when the king recovers from his injury. All known regents have also taken the title of "Protector of the Realm", a title usually reserved for the king.
- Queen Alyssa Velaryon served as Queen Regent during the first two years of the reign of her son King Jaehaerys I Targaryen.
- Prince Aemond Targaryen became Prince Regent after his brother, King Aegon II Targaryen, was severely wounded and incapacitated for a year after the Battle of Rook's Rest during the civil war known as the Dance of the Dragons.
- The Regency of Aegon III featured a council of seven regents. Regents were replaced as they resigned or died, the last three being chosen by the Great Council of 136.
- Eddard Stark in the will of Robert Baratheon was named Lord Regent to Joffrey Baratheon, but his regency never transpired.
- Cersei Lannister declared herself Queen Regent to Joffrey after Eddard Stark was arrested, and after the murders of Joffrey and her father Tywin Lannister named herself regent to Tommen Baratheon.
- Kevan Lannister is made Lord Regent to Tommen after Cersei's imprisonment by the Faith of the Seven.