Wayfarer's Rest is the seat of House Vance of Wayfarer's Rest in the riverlands.
Queen Rhaena Targaryen and her dragon, Dreamfyre, briefly stayed with the Vances of Wayfarer's Rest.
Karyl Vance becomes Lord of Wayfarer's Rest after the death of his father in the battle in the hills below the Golden Tooth.
After the Battle of Oxcross, captives such as Ser Lymond Vikary are held here.
Wayfarer's Rest is a reference by George R. R. Martin to Liane the Wayfarer from The Dying Earth by Jack Vance.